LC-MS/MS analysis of uncommon paracetamol metabolites derived through in vitro polymerization and nitration reactions in liquid nitrogen.

LC-MS/MS analysis of uncommon paracetamol metabolites derived through in vitro polymerization and nitration reactions in liquid nitrogen.

Paracetamol (acetaminophen, APAP) is a generally used analgesic drug. Known paracetamol metabolites embody the glucuronide, sulfate and mercapturate. N-Acetyl-benzoquinonimine (NAPQI) is taken into account the poisonous intermediate metabolite of paracetamol. In vitro and in vivo research point out that paracetamol can also be metabolized to extra poorly characterised metabolites. For instance, metabolomic research in urine …

LC-MS/MS analysis of uncommon paracetamol metabolites derived through in vitro polymerization and nitration reactions in liquid nitrogen. Read More ยป