Validity, potential clinical utility and comparison of a consumer activity tracker and a research-grade activity tracker in insomnia disorder II: Outside the laboratory.

Accurate assessment of sleep can be fundamental for monitoring, managing and evaluating treatment outcomes within diseases. A proliferation of consumer activity trackers gives easy access to objective sleep. We evaluated the performance of a commercial device (Fitbit Alta HR) relative to a research-grade actigraph (Actiwatch Spectrum Pro) in measuring sleep before and after a cognitive behavioural intervention in insomnia disorder.

Twenty-five individuals with DSM-5 insomnia disorder (M = 50.6 ± 15.9 years) wore Fitbit and Actiwatch and completed a sleep diary during an in-laboratory polysomnogram, and for 1 week preceding and following seven weekly sessions of cognitive-behavioural intervention for insomnia. Device performance was compared for sleep outcomes (total sleep time, sleep latency, sleep efficiency and wake after sleep onset).

Rabbit IS ELISA Kit
ERTI0046	Abclonal	96Tests	EUR 521

Mouse IS ELISA Kit
EMI0046	Abclonal	96Tests	EUR 521

Monkey IS ELISA Kit
EMKI0046	Abclonal	96Tests	EUR 521

Porcine IS ELISA Kit
EPI0046	Abclonal	96Tests	EUR 521

Human IS ELISA Kit
EHI0046	Abclonal	96Tests	EUR 521

Canine IS ELISA Kit
ECI0046	Abclonal	96Tests	EUR 521

Chicken IS ELISA Kit
ECKI0046	Abclonal	96Tests	EUR 521

Bovine IS ELISA Kit
EBI0046	Abclonal	96Tests	EUR 521

Goat IS ELISA Kit
EGTI0046	Abclonal	96Tests	EUR 521

IS ELISA KIT|Human
EF007501	Lifescience Market	96 Tests	EUR 689

AP homeodomain antibody
70R-AR021	Fitzgerald	100 ug	EUR 300
Description: Affinity purified Rabbit polyclonal AP homeodomain antibody

Guinea Pig IS ELISA Kit
EGI0046	Abclonal	96Tests	EUR 521

Goat Anti-Human Apolipoprotein A-IV A(ApoA4) peptid IgG, aff pure
APOA45-A	Alpha Diagnostics	100 ul	EUR 482

Rabbit Anti-human MART-1/Melanocyte Differentiation-A/Melan-A peptide (CT) IgG
MART12-A	Alpha Diagnostics	100 ul	EUR 445

Human Serum Indoxyl Sulfate (IS) ELISA Kit
abx257961-96tests	Abbexa	96 tests	EUR 746

Human IS(serum indoxyl sulfate) ELISA Kit
EH4913	FN Test	96T	EUR 567.6
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75 ng/ml

Boc-a-Me-DL-Val-OH
A-4145.0001	Bachem	1.0g	EUR 139
Description: Sum Formula: C11H21NO4; CAS# [139938-00-4]

Boc-a-Me-DL-Val-OH
A-4145.0005	Bachem	5.0g	EUR 477
Description: Sum Formula: C11H21NO4; CAS# [139938-00-4]

Recombinant Homeodomain Only Protein (HOP)
4-RPC532Hu01	Cloud-Clone	EUR 440.48 EUR 221.00 EUR 1376.80 EUR 525.60 EUR 951.20 EUR 358.00 EUR 3292.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Homeodomain Only Protein expressed in: E.coli

Recombinant Homeodomain Only Protein (HOP)
4-RPC532Mu01	Cloud-Clone	EUR 462.88 EUR 227.00 EUR 1460.80 EUR 553.60 EUR 1007.20 EUR 373.00 EUR 3502.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Homeodomain Only Protein expressed in: E.coli

Homeodomain Only Protein (HOP) Antibody
20-abx131159	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Homeodomain Only Protein (HOP) Antibody
20-abx131160	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Homeodomain-Only Protein (HOPX) Antibody
20-abx113060	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Paired-Like Homeodomain 1 Antibody
20-abx114314	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Paired-Like Homeodomain 2 Antibody
20-abx114315	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Homeodomain-Only Protein (HOPX) Antibody
20-abx123464	Abbexa	EUR 411.00 EUR 592.00	100 ul 200 ul

Homeodomain-Only Protein (HOPX) Antibody
abx038004-100ug	Abbexa	100 ug	EUR 391

Homeodomain Only Protein (HOP) Antibody
20-abx148844	Abbexa	EUR 425.00 EUR 342.00	100 ug 50 ug

Homeodomain-Only Protein (HOPX) Protein
20-abx260919	Abbexa	EUR 3418.00 EUR 328.00 EUR 230.00	1 mg 20 ug 5 ug

Homeodomain-Only Protein (HOPX) Antibody
abx233970-100ug	Abbexa	100 ug	EUR 481

Homeodomain-Only Protein (HOPX) Antibody
20-abx301640	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Rabbit Anti-Influenza A HA (H1N1, 1-343aa) (A/Wyoming/3/03) protein IgG, aff pure
H3N22-A	Alpha Diagnostics	100 ul	EUR 445

Fmoc-a-amino-DL-Gly(Boc)-OH
A-4320.0001	Bachem	1.0g	EUR 273
Description: Sum Formula: C22H24N2O6; CAS# [176039-39-7]

Fmoc-a-amino-DL-Gly(Boc)-OH
A-4320.0005	Bachem	5.0g	EUR 998
Description: Sum Formula: C22H24N2O6; CAS# [176039-39-7]

Chicken Anti-Protein A IgG, aff pure
PRTA11-A	Alpha Diagnostics	1 mg	EUR 482

Goat Anti-Protein-A IgG aff pure
PRTA12-A	Alpha Diagnostics	0.1 ml	EUR 408

Chicken Anti-Protein-A IgG aff pure
PRTA13-A	Alpha Diagnostics	100 ug	EUR 408

Rabbit Anti-Influenza A nucleoprotein (H1N1-NP/1-320aa) protein (A/06/California/2009) IgG, aff pure
H1NP21-A	Alpha Diagnostics	100 ul	EUR 445

Rabbit Anti-Influenza A HA2 (H5N1) (A/Vietnam/1203/2004 366-531aa, >95%, his-tag) protein IgG
HA2H012-A	Alpha Diagnostics	100 ul	EUR 445

Rabbit Anti-Influenza A HA (H3N2, 1-531aa/HA1+HA2) (A/Brisbane/10/2007) protein IgG, aff pure
H3N23-A	Alpha Diagnostics	100 ul	EUR 445

Goat Anti-human Serum Amyloid A (SAA) antiserum
SAA11-A	Alpha Diagnostics	100 ul	EUR 482

Rabbit Anti-Streptococcus A IgG, aff pure, #2
STA12-A	Alpha Diagnostics	1 mg	EUR 286

Goat Anti-Hepatitis A Virus (Strain HM175) IgG
HAV11-A	Alpha Diagnostics	100 ul	EUR 457

Chicken Anti-Human+Mouse IgG+A+M IgG/Y
HGAM11-A	Alpha Diagnostics	100 ul	EUR 482

Rabbit Anti-Human Calcineurin A-subunit IgG aff pure
CALNA12-A	Alpha Diagnostics	100 ug	EUR 482

Paired Like Homeodomain 3 (PITX3) Antibody
20-abx126368	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Homeodomain-Only Protein (HOPX) Antibody (HRP)
20-abx310547	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Homeodomain-Only Protein (HOPX) Antibody (FITC)
20-abx310548	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Homeodomain-Only Protein (HOPX) Antibody (Biotin)
20-abx310549	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Paired Like Homeodomain 3 (PITX3) Antibody
20-abx317848	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Human Homeodomain Only Protein (HOP) Protein
20-abx650019	Abbexa	EUR 620.00 EUR 272.00 EUR 1859.00 EUR 732.00 EUR 453.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Homeodomain Only Protein (HOP) Protein
20-abx650020	Abbexa	EUR 648.00 EUR 272.00 EUR 1970.00 EUR 773.00 EUR 467.00	100 ug 10 ug 1 mg 200 ug 50 ug

Paired Like Homeodomain 3 (PITX3) Antibody
abx433138-200ul	Abbexa	200 ul	EUR 384

Paired Like Homeodomain 3 (PITX3) Antibody
20-abx241987	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul

Paired Like Homeodomain 3 (PITX3) Antibody
20-abx212262	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul

Hematoxylin, Weigert's Iron (Part A)
HWI-A-250	ScyTek Laboratories	250 ml	EUR 116

Rabbit Anti-Rat/Human Orexin-A IgG # 1, aff pure
OXA11-A	Alpha Diagnostics	100 ug	EUR 482

Rabbit Anti-Mouse prepro Orexin A IgG # 1, aff pure
PPOX11-A	Alpha Diagnostics	100 ul	EUR 482

Goat Anti-Green Fluorescent Proteins (GFP, A. victoria) protein, IgG
GFP11-A	Alpha Diagnostics	100 ul	EUR 408

Rabbit Anti-Mouse a-1-Acid Glycoprotein IgG, aff pure
A1AG18-A	Alpha Diagnostics	100 ug	EUR 482

Rabbit Anti-Rat a-1-Acid Glycoprotein IgG, aff pure
A1AG19-A	Alpha Diagnostics	100 ug	EUR 482

Rabbit Anti-Human Apolipoprotein A-I protein IgG, aff pure
APOA12-A	Alpha Diagnostics	100 ug	EUR 482

Rabbit Anti-Mouse Apolipoprotein A-I protein IgG, aff pure
APOA13-A	Alpha Diagnostics	100 ug	EUR 482

Goat Anti-Human Apolipoprotein A-Il protein IgG, aff pure
APOA21-A	Alpha Diagnostics	100 ug	EUR 482

Rabbit Anti-Influenza A hemeagglutinin A2 (HA2/stem or stalk domain/347-523aa) protein (A/Viet Nam/1203/2004(H5N1) IgG, aff pure
HA28-A	Alpha Diagnostics	100 ul	EUR 445

Rabbit Phosphorylase b kinase regulatory subunit alpha, liver is
ELI-08786Ra	Lifescience Market	96 Tests	EUR 928

Rabbit Anti-Borrelia burgdorferi Osp-A protein (OspA) IgG, aff pure
OSPA12-A	Alpha Diagnostics	100 ul	EUR 482

Rabbit Anti-bovine Calcineurin (A+B subunits) protein, IgG, aff pure
CALN11-A	Alpha Diagnostics	100 ug	EUR 482

Rabbit Anti-Hemagglutinin HA1 Influenza A Virus (H11N2; A/duck/Yangzhou/906/2002) IgG
H11N2-01-A	Alpha Diagnostics	100 ul	EUR 482

Rabbit Anti-Hemagglutinin Influenza A Virus H1N1 H1 (H1N1) (A/New Caledonia/20/99) IgG
H1N1-01-A	Alpha Diagnostics	100 ul	EUR 482

Rabbit Anti-Rat neurite outgrowth inhibitor (Nogo-A) IgG #1, aff. pure
NogoA11-A	Alpha Diagnostics	100 ug	EUR 482

Goat Anti-Human/mouse/rat Insulin chain A peptide IgG, aff pure
INSA21-A	Alpha Diagnostics	100 ul	EUR 482

Recombinant Homeodomain Interacting Protein Kinase 4 (HIPK4)
4-RPF475Hu01	Cloud-Clone	EUR 413.60 EUR 214.00 EUR 1276.00 EUR 492.00 EUR 884.00 EUR 340.00 EUR 3040.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Homeodomain Interacting Protein Kinase 4 expressed in: E.coli

Recombinant Homeodomain Interacting Protein Kinase 3 (HIPK3)
4-RPF476Hu01	Cloud-Clone	EUR 413.60 EUR 214.00 EUR 1276.00 EUR 492.00 EUR 884.00 EUR 340.00 EUR 3040.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Homeodomain Interacting Protein Kinase 3 expressed in: E.coli

Recombinant Homeodomain Interacting Protein Kinase 3 (HIPK3)
4-RPF476Mu01	Cloud-Clone	EUR 449.44 EUR 223.00 EUR 1410.40 EUR 536.80 EUR 973.60 EUR 364.00 EUR 3376.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Homeodomain Interacting Protein Kinase 3 expressed in: E.coli

Recombinant Homeodomain Interacting Protein Kinase 2 (HIPK2)
4-RPF477Hu01	Cloud-Clone	EUR 476.32 EUR 230.00 EUR 1511.20 EUR 570.40 EUR 1040.80 EUR 382.00 EUR 3628.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Homeodomain Interacting Protein Kinase 2 expressed in: E.coli

Homeodomain Only Protein (HOP) Polyclonal Antibody (Human)
4-PAC532Hu01	Cloud-Clone	EUR 247.00 EUR 2510.00 EUR 625.00 EUR 310.00 EUR 214.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Homeodomain Only Protein (HOP)

Homeodomain Only Protein (HOP) Polyclonal Antibody (Mouse)
4-PAC532Mu01	Cloud-Clone	EUR 251.00 EUR 2576.00 EUR 640.00 EUR 316.00 EUR 215.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Homeodomain Only Protein (HOP)

Recombinant Homeodomain Interacting Protein Kinase 1 (HIPK1)
4-RPC526Hu01	Cloud-Clone	EUR 476.32 EUR 230.00 EUR 1511.20 EUR 570.40 EUR 1040.80 EUR 382.00 EUR 3628.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Homeodomain Interacting Protein Kinase 1 expressed in: E.coli

Homeodomain Interacting Protein Kinase 2 (HIPK2) Antibody
20-abx128325	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Homeodomain Interacting Protein Kinase 1 (HIPK1) Antibody
20-abx131354	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Homeodomain Interacting Protein Kinase 2 (HIPK2) Antibody
abx122745-100ug	Abbexa	100 ug	EUR 391

Homeodomain Interacting Protein Kinase 2 (HIPK2) Antibody
20-abx124184	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Putative Homeodomain Transcription Factor 2 (PHTF2) Antibody
abx036603-100ug	Abbexa	100 ug	EUR 391

Homeodomain Interacting Protein Kinase 1 (HIPK1) Antibody
abx145234-100ug	Abbexa	100 ug	EUR 391

Homeodomain-Interacting Protein Kinase 4 (HIPK4) Antibody
abx145598-100ug	Abbexa	100 ug	EUR 391

Homeodomain Interacting Protein Kinase 2 (HIPK2) Antibody
20-abx008183	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul

Homeodomain-Interacting Protein Kinase 4 (HIPK4) Antibody
20-abx013698	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg

Putative Homeodomain Transcription Factor 2 (PHTF2) Antibody
abx025714-400ul	Abbexa	400 ul	EUR 523

Putative Homeodomain Transcription Factor 2 (PHTF2) Antibody
abx025714-80l	Abbexa	80 µl	EUR 286

Homeodomain Interacting Protein Kinase 1 (HIPK1) Antibody
abx026832-400ul	Abbexa	400 ul	EUR 523

Homeodomain Interacting Protein Kinase 1 (HIPK1) Antibody
abx026832-80l	Abbexa	80 µl	EUR 286

Homeodomain-Interacting Protein Kinase 4 (HIPK4) Antibody
abx027094-400ul	Abbexa	400 ul	EUR 523

Homeodomain-Interacting Protein Kinase 4 (HIPK4) Antibody
abx027094-80l	Abbexa	80 µl	EUR 286

Homeodomain-Interacting Protein Kinase 4 (HIPK4) Antibody
abx033195-400ul	Abbexa	400 ul	EUR 523

Homeodomain-Interacting Protein Kinase 4 (HIPK4) Antibody
abx033195-80l	Abbexa	80 µl	EUR 286

The analyses assessed (a) agreement between devices across days and pre- to post-treatment, and (b) whether pre- to post-treatment changes in sleep assessed by devices correlated with clinical measures of change. Devices generally did not significantly differ from each other on sleep variable estimates, either night to night, in response to sleep manipulation (pre- to post-treatment) or in response to changes in environment (in the laboratory versus at home).

Change in sleep measures across time from each device showed some correlation with common clinical measures of change in insomnia, but not insomnia diagnosis as a categorical variable. Overall, the Fitbit provides similar estimates of sleep outside the laboratory to a research grade actigraph. Despite the similarity between Fitbit and Actiwatch performance, the use of consumer technology is still in its infancy and caution should be taken in its interpretation.